Keiichi Ozono Selected Research

asfotase alfa

11/2020	Burden of Illness in Adults With Hypophosphatasia: Data From the Global Hypophosphatasia Patient Registry.
3/2020	Effect of Asfotase Alfa on Muscle Weakness in a Japanese Adult Patient of Hypophosphatasia with Low ALP Levels.
1/2020	Case Report: Efficacy of Reduced Doses of Asfotase Alfa Replacement Therapy in an Infant With Hypophosphatasia Who Lacked Severe Clinical Symptoms.
7/2017	Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial.
1/2017	Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa.
1/2016	Asfotase Alfa Treatment Improves Survival for Perinatal and Infantile Hypophosphatasia.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Keiichi Ozono Research Topics

Disease

21	Neoplasms (Cancer) 06/2022 - 01/2006
21	Hypophosphatasia 12/2020 - 05/2005
19	Rickets (Rachitis) 05/2022 - 06/2010
15	Hypophosphatemia 12/2021 - 01/2002
12	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 05/2022 - 01/2005
12	Osteomalacia 01/2020 - 01/2007
10	Infections 10/2018 - 05/2007
9	Hypocalcemia 01/2017 - 12/2005
8	Hypercalcemia (Milk Alkali Syndrome) 01/2017 - 12/2005
7	Achondroplasia 01/2022 - 10/2012
7	Vitamin D Deficiency 05/2021 - 01/2003
7	Bone Resorption 05/2015 - 05/2008
6	Bone Diseases (Bone Disease) 01/2020 - 01/2009
6	Metabolic Bone Diseases (Osteopenia) 04/2019 - 01/2006
6	Globoid Cell Leukodystrophy (Krabbe Disease) 06/2018 - 04/2005
5	Hypoxia (Hypoxemia) 04/2016 - 04/2007
5	Mucolipidoses (Sialidosis) 02/2012 - 03/2009
4	Wilms Tumor (Wilm's Tumor) 06/2022 - 06/2006
4	Osteogenesis Imperfecta (Lobstein Disease) 01/2021 - 09/2011
4	Metabolic Diseases (Metabolic Disease) 12/2020 - 09/2008
4	Down Syndrome (Down's Syndrome) 01/2020 - 02/2008
4	Hypophosphatemic Rickets 05/2017 - 01/2013
4	Secondary Hyperparathyroidism 01/2017 - 01/2006
4	Demyelinating Diseases (Demyelinating Disease) 01/2014 - 04/2005
3	Inflammation (Inflammations) 10/2022 - 04/2006
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2022 - 04/2010
3	Disease Progression 11/2021 - 09/2017
3	Hypertension (High Blood Pressure) 10/2021 - 06/2005
3	Mucopolysaccharidoses 09/2021 - 02/2012
3	Seizures (Absence Seizure) 06/2021 - 12/2011
3	Pain (Aches) 11/2020 - 01/2017
3	Congenital Abnormalities (Deformity) 03/2020 - 02/2019
3	Allan-Herndon-Dudley syndrome 01/2019 - 07/2008
3	Hyperphosphatemia 07/2017 - 08/2007
3	Pulmonary Arterial Hypertension 01/2016 - 01/2013
3	Osteoporosis 07/2014 - 01/2006
3	Hypercalciuria 12/2013 - 06/2004
3	Fibrosis (Cirrhosis) 12/2012 - 11/2003
3	Leukemia 04/2010 - 11/2006
3	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 11/2009 - 03/2009
3	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome) 07/2009 - 01/2002
2	Pruritus (Itching) 02/2022 - 07/2014
2	Hematoma 02/2022 - 04/2002
2	Failure to Thrive 02/2022 - 02/2019
2	Familial Hypophosphatemia (Phosphate Diabetes) 12/2021 - 08/2005
2	Pulmonary Hypertension 10/2021 - 04/2007
2	Precocious Puberty 01/2021 - 01/2009
2	Noonan Syndrome (Female Pseudo-Turner Syndrome) 08/2020 - 02/2018

Drug/Important Bio-Agent (IBA)

20	Alkaline PhosphataseIBA 12/2021 - 05/2005
17	CalciumIBA 01/2020 - 06/2004
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2004
15	Vitamin D FDA LinkGeneric 07/2021 - 01/2003
14	Fibroblast Growth Factor-23IBA 10/2022 - 01/2005
13	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 12/2020 - 01/2016
12	Phosphates (Orthophosphate)IBA 01/2020 - 01/2005
8	Hormones (Hormone)IBA 01/2018 - 08/2007
8	EnzymesIBA 01/2017 - 03/2009
6	Growth Hormone (Somatotropin)IBA 01/2022 - 09/2006
6	asfotase alfaIBA 11/2020 - 01/2016
6	MineralsIBA 01/2017 - 10/2012
5	1,25-dihydroxyvitamin DIBA 07/2021 - 01/2005
5	hydroxide ionIBA 05/2017 - 04/2004
4	vosoritideIBA 01/2022 - 01/2020
4	25-hydroxyvitamin DIBA 07/2021 - 01/2006
4	Parathyroid Hormone (Parathormone)IBA 07/2021 - 01/2007
4	4-phenylbutyric acid (Buphenyl)FDA Link 01/2021 - 07/2014
4	Pharmaceutical PreparationsIBA 01/2021 - 04/2005
4	Thyroid HormonesIBA 01/2019 - 07/2008
4	Dihydrotachysterol (AT 10)IBA 10/2016 - 01/2005
4	Peptides (Polypeptides)IBA 08/2010 - 11/2003
3	AntigensIBA 06/2022 - 04/2010
3	Biomarkers (Surrogate Marker)IBA 05/2022 - 10/2018
3	burosumabIBA 05/2022 - 02/2019
3	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2022 - 05/2015
3	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 12/2021 - 10/2012
3	GlycosaminoglycansIBA 09/2021 - 02/2012
3	CreatinineIBA 07/2021 - 12/2013
3	RNA (Ribonucleic Acid)IBA 01/2021 - 02/2008
3	Diphosphonates (Bisphosphonates)IBA 05/2019 - 01/2006
3	Pamidronate (Aredia)FDA LinkGeneric 05/2019 - 09/2011
3	GalactosylceramidaseIBA 06/2018 - 01/2014
3	Psychosine (Galactosylsphingosine)IBA 06/2018 - 04/2005
3	DNA (Deoxyribonucleic Acid)IBA 07/2008 - 11/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2022 - 04/2005
2	VaccinesIBA 06/2022 - 08/2010
2	PHEX Phosphate Regulating Neutral EndopeptidaseIBA 12/2021 - 01/2020
2	Semaxinib (SU5416)IBA 10/2021 - 01/2016
2	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 06/2021 - 01/2017
2	Human Growth Hormone (Saizen)FDA LinkGeneric 08/2020 - 02/2018
2	Protein AggregatesIBA 01/2020 - 01/2019

Therapy/Procedure

32	Therapeutics 01/2020 - 01/2002
11	Hematopoietic Stem Cell Transplantation 10/2016 - 12/2008
7	Drug Therapy (Chemotherapy) 01/2020 - 12/2008
4	Immunotherapy 06/2022 - 01/2009
4	Transplantation 01/2016 - 09/2008
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/2014 - 10/2007
3	Enzyme Replacement Therapy 01/2020 - 02/2014
2	Artificial Respiration (Mechanical Ventilation) 10/2021 - 08/2016
2	Subcutaneous Injections 01/2021 - 04/2012
2	Osteotomy 01/2021 - 05/2019